PRIORITY Results

Clinical Presentation of Coronavirus Disease 2019 (COVID-19) in Pregnant and Recently Pregnant People​

Yalda Afshar, MD, PHD, Stephanie L Gaw, MD, PHD, Valerie J Flaherman, MD, MPH, Brittany D Chambers, PHD, Deborah Krakow, MD, Vincenzo Berghella, MD, Alireza A Sharmshirsaz, MD, Adeline A Boatin, MD, MPH, Grace Aldrovandi, MD, Andrea Greiner, MD, MHA, Laura Riley, MD, W. John Boscardin, PHD, Denise J Jamieson, MD, MPH, Vanessa L Jacoby, MD, MAS. Obstetrics & Gynecology, Online ahead of print: 7 October 2020

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The main study results are:

  • This is the first nationwide study of pregnant people with COVID-19 where most of the participants are not hospitalized with COVID-19 (95%).
  • The most common first symptoms were cough (20%), sore throat (16%), body aches (12%).
  • Fever was an uncommon first symptom, occurring in just 12% of participants.
  • Loss of taste or smell was the first symptom in 6%
  • The median time until participants had no symptoms was 5 weeks and 2 days
  • 60% of participants had no symptoms by 4 weeks
  • 25% had persistent symptoms at 8 weeks (5% cough and 8% loss of smell/taste).  
  • Participants with symptoms, but who tested negative for COVID-19 also had symptoms last for many weeks. This highlights that infection from any cause can have a big impact on health and well-being.

 

Infant Outcomes Following Maternal Infection with SARS-CoV-2: First Report from the PRIORITY Study

Valerie J Flaherman, MD, MPH, Yalda Afshar, MD, PHD, John Boscardin, PHD, Roberta L Keller, MD, Anne Mardy, MD, Mary K Prahl, MD, Carolyn Phillips, MD, Ifeyinwa V Asiodu, RN, PHD, W Vincenzo Berghella, MD, Brittany D Chambers, PHD, Joia Crear-Perry, MD, Denise J Jamieson, MD, MPH, Vanessa L Jacoby, MD, MAS, Stephanie L Gaw, MD, PHD.
Clinical Infectious Diseases, Published: 18 September 2020

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The main results of the study are:

  • Most of the 179 babies born to participants who had COVID-19 were healthy.
  • Babies born to participants with COVID-19 did not have more problems with breathing or need to be in the intensive care unit compared with babies born to participants who did not have COVID-19.
  • No babies had respiratory infections, pneumonia, or a need to be hospitalized in the first 6 weeks after birth.  
  • Babies that were born to participants who had COVID-19 within 2 weeks of the delivery had a higher chance of being in the intensive care unit compared with participants who had COVID-19 further out from delivery.